abstract：:Regional cerebral blood flow (rCBF) was measured with the 133Xenon clearance technique and a high resolution (254 detectors) scanner during the performance of a verbal and a facial memory task in 18 patients with schizophrenia and 18 sociodemographically matched controls. Patients and controls had comparable resting r...

journal_title：Biological psychiatry

authors： Gur RE,Jaggi JL,Shtasel DL,Ragland JD,Gur RC

更新日期：1994-01-01 00:00:00

abstract：:Cell lines of continuously dividing human olfactory neuroblasts can be propagated using olfactory epithelium obtained from human donors at biopsy or autopsy. The expression of neuronal proteins in these cells, such as neurofilament protein and tau protein, can be increased using a combination of factors including nerv...

journal_title：Biological psychiatry

authors： Wolozin B,Lesch P,Lebovics R,Sunderland T

更新日期：1993-12-15 00:00:00

abstract：:The total number of neurons was estimated in eight brains from chronic schizophrenic men and compared with 16 gender- and age-matched controls. The average total neocortical nerve cell number was 22.12.10(9) in schizophrenics and 22.06.10(9) in controls. The estimate of total cell numbers can not demonstrate more subt...

journal_title：Biological psychiatry

authors： Pakkenberg B

更新日期：1993-12-01 00:00:00

abstract：:Using magnetic resonance imaging (MRI), we measured the volumes of various brain structures and cerebrospinal fluid (CSF) in 19 men with dementia of the Alzheimer type (DAT) and 18 healthy age-matched control men. The mean (+/- S.D) Mini-Mental State exam score (MMSE) of the DAT men was 16 +/- 7; 9 were mildly (MMSE >...

journal_title：Biological psychiatry

authors： Murphy DG,DeCarli CD,Daly E,Gillette JA,McIntosh AR,Haxby JV,Teichberg D,Schapiro MB,Rapoport SI,Horwitz B

更新日期：1993-11-01 00:00:00

abstract：:The levels of the synaptic vesicle-associated proteins, synapsin and synaptophysin, were examined in human postmortem hippocampus from the brains of schizophrenics and age-matched controls using a quantitative western blot analysis. The schizophrenic samples had significantly lower levels of synapsin I than controls. ...

journal_title：Biological psychiatry

authors： Browning MD,Dudek EM,Rapier JL,Leonard S,Freedman R

更新日期：1993-10-15 00:00:00

abstract：:Disturbances in dopaminergic transmission have been implicated in the etiology of psychotic disorders. Interindividual differences in deoxyribonucleic acid (DNA) sequences coding for dopamine receptor proteins might contribute to the genetic background of these diseases. We have identified a variation in exon 1 of the...

journal_title：Biological psychiatry

authors： Catalano M,Nobile M,Novelli E,Nöthen MM,Smeraldi E

更新日期：1993-10-01 00:00:00

abstract：:Autonomic characteristics of nonclinical panic and blood phobia were compared using spectral analysis of the electrocardiogram (EKG), as well as more conventional cardiovascular measures. The cardiovascular responses of 11 subjects who reported recent occurrence of frequent severe panic attacks, and 10 subjects who re...

journal_title：Biological psychiatry

authors： Friedman BH,Thayer JF,Borkovec TD,Tyrrell RA,Johnson BH,Columbo R

更新日期：1993-09-01 00:00:00

abstract：:The authors examined thyrotropin-releasing hormone (TRH) stimulation testing in the neuroendocrine evaluation of DSM-III major depressive disorder in 26 consecutive medication-free, medically healthy patients meeting a primary DSM-III diagnosis of axis II personality disorder. Thyroid-stimulating hormone (TSH) respons...

journal_title：Biological psychiatry

authors： Kavoussi RJ,Coccaro EF,Klar H,Lesser J,Siever LJ

更新日期：1993-08-15 00:00:00

abstract：:The prevalence and role of sleep disorders in the sexual problems of diabetic patients remain unexplored. This study was conducted on 40 diabetic men carefully screened to exclude the confounding effects of other medical illnesses or drugs likely to impair sexual function and 40 age-matched healthy volunteers. They un...

journal_title：Biological psychiatry

authors： Schiavi RC,Stimmel BB,Mandeli J,Rayfield EJ

更新日期：1993-08-01 00:00:00

abstract：:Pre-treatment and posttreatment dexamethasone suppression test (DST) results in physically healthy elderly major depressives without dementia demonstrated an association between treatment and DST normalization. Sixty percent of subjects were nonsuppressors at baseline compared to 17% after intensive treatment. DST res...

journal_title：Biological psychiatry

authors： Meyers BS,Alpert S,Gabriele M,Kakuma T,Kalayam B,Alexopoulos GS

更新日期：1993-07-01 00:00:00

abstract：:Fifteen subjects dependent on both opioids and cocaine completed an ascending and tapering schedule of buprenorphine dosing, with maintenance for 21 days at each dose of buprenorphine (4, 8, 12, 16 mg sublingual daily) during both ascending and tapering phases. Higher doses of buprenorphine led to greater reductions i...

journal_title：Biological psychiatry

authors： Schottenfeld RS,Pakes J,Ziedonis D,Kosten TR

更新日期：1993-07-01 00:00:00

abstract：:The acoustic startle response (ASR) and midlatency auditory evoked potentials (AEP) have been utilized in the measurement of sensory inhibition. Using these different paradigms, abnormalities suggesting a lack of normal inhibition have been noted in a number of psychiatric syndromes. To date, the most commonly used se...

journal_title：Biological psychiatry

authors： Schwarzkopf SB,Lamberti JS,Smith DA

更新日期：1993-06-01 00:00:00

abstract：:The preattentive automatic processing of 63 alcoholics and 27 controls was evaluated with an auditory inattentive event-related oddball paradigm. We examined the mismatch negativity and the N2-P3 complex. Results showed significantly greater amplitude for N2, P3 and the N2-P3 complex for controls but no individual lea...

journal_title：Biological psychiatry

authors： Realmuto G,Begleiter H,Odencrantz J,Porjesz B

更新日期：1993-04-15 00:00:00

abstract：:The effect of 80%-90% neuroleptic dose reductions on neuropsychological function in schizophrenic and schizoaffective patients was examined in a prospective study. A neuropsychological battery was administered in the week prior to neuroleptic reduction followed by retesting at least 6 weeks postreduction. Patients wer...

journal_title：Biological psychiatry

authors： Seidman LJ,Pepple JR,Faraone SV,Kremen WS,Green AI,Brown WA,Tsuang MT

更新日期：1993-04-15 00:00:00

abstract：:Cerebrospinal fluid (CSF) concentrations of the serotonin and dopamine metabolites, 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA), respectively, were measured in a group of 17 children with Autistic Disorder (DSM-III-R). The group means observed for 5HIAA (135 +/- 91 nmol/L) and HVA (502 +/- 324 nmol/...

journal_title：Biological psychiatry

authors： Narayan M,Srinath S,Anderson GM,Meundi DB

更新日期：1993-04-15 00:00:00

abstract：:Several lines of evidence suggest that the anticonvulsant drug valproate may have antipanic properties: (1) It enhances gamma-aminobutyric acid activity in the brain; (2) it has anxiolytic effects in animal models of anxiety; and (3) it has been reported to be effective in panic disorder in several preliminary studies...

journal_title：Biological psychiatry

authors： Keck PE Jr,Taylor VE,Tugrul KC,McElroy SL,Bennett JA

更新日期：1993-04-01 00:00:00

abstract：:Depersonalization and other behavioral and physiological indices were monitored before and after the administration of high- and low-potency marijuana cigarettes and a placebo cigarette in 35 physically and mentally healthy normal volunteers. The cigarettes were administered under double-blind conditions during three ...

journal_title：Biological psychiatry

authors： Mathew RJ,Wilson WH,Humphreys D,Lowe JV,Weithe KE

更新日期：1993-03-15 00:00:00

abstract：:The sleep parameters of never-depressed borderline subjects and age- and sex-matched normal controls were compared by continuous 48-hr ambulatory electroencephalographic (EEG) monitoring. Borderline subjects had a significantly shorter rapid eye movement latency, normal architecture of rapid eye movements sleep, and h...

journal_title：Biological psychiatry

authors： Battaglia M,Ferini-Strambi L,Smirne S,Bernardeschi L,Bellodi L

更新日期：1993-03-01 00:00:00

abstract：:Eleven patients with senile dementia of the Alzheimer type and 11 age-matched control subjects were given the thyrotropin-releasing hormone (TRH) test. The two groups did not differ with respect to peak thyrotropin (TSH) response or TSH levels at baseline, 20, 30, and 45 min after TRH injection. There were significant...

journal_title：Biological psychiatry

authors： Albert M,Jenike M,Nixon R,Nobel K

更新日期：1993-02-15 00:00:00

abstract：:Thirty-nine patients with major depression were studied to determine the differential effects of desipramine (DMI) and fluoxetine (FLU) on thyroid hormones. Twenty-six percent showed some abnormality in baseline thyroid hormone levels. There were no demonstrable differences for any of the thyroid indices from baseline...

journal_title：Biological psychiatry

authors： Shelton RC,Winn S,Ekhatore N,Loosen PT

更新日期：1993-01-15 00:00:00

abstract：:The addition of lithium to perphenazine altered the pattern of plasma homovanillic acid (HVA) during the course of treatment for acute psychosis. In the perphenazine-treated group plasma HVA declined significantly by days 7-9 of treatment, whereas in the perphenazine-plus-lithium group plasma HVA tended to increase. T...

journal_title：Biological psychiatry

authors： Bowers MB Jr,Mazure CM,Nelson JC,Jatlow PI

更新日期：1992-12-15 00:00:00

abstract：:The syndrome of chronic fatigue, feverishness, diffuse pains, and other constitutional complaints, often precipitated by an acute infectious illness and aggravated by physical and emotional stressors, has a lengthy history in the medical literature. The Centers for Disease Control (CDC) recently formulated a case defi...

journal_title：Biological psychiatry

authors： Demitrack MA,Gold PW,Dale JK,Krahn DD,Kling MA,Straus SE

更新日期：1992-12-15 00:00:00

abstract：:Several lines of evidence suggest that dopamine might be involved in anxiety states. In this study, we assessed the growth hormone (GH) response to apomorphine (a dopaminergic agonist) 0.5 mg SC in nine drug-free inpatients meeting Research Diagnostic Criteria (RDC) for panic disorder who were age-matched and gender-m...

journal_title：Biological psychiatry

authors： Pitchot W,Ansseau M,Gonzalez Moreno A,Hansenne M,von Frenckell R

更新日期：1992-12-01 00:00:00

abstract：:The long-term test-retest reliability of event-related potentials (ERP) measures was examined in a group of 44 controls and 71 chronic alcoholics, retested after an average of 14 months. Correlational analyses revealed moderately significant test-retest correlations for visual and auditory target N1, N2, and P3 amplit...

journal_title：Biological psychiatry

authors： Sinha R,Bernardy N,Parsons OA

更新日期：1992-12-01 00:00:00

abstract：:Patients with chronic hypercortisolemia due to Cushing's syndrome (CS) exhibit cognitive dysfunction. Because glucocorticoid excess is associated with hippocampal damage in animals, and the hippocampus participates in learning and memory, we explored the relationships between hippocampal formation (HF) volume, memory ...

journal_title：Biological psychiatry

authors： Starkman MN,Gebarski SS,Berent S,Schteingart DE

更新日期：1992-11-01 00:00:00

abstract：:Auditory event-related potentials (ERPs) associated with selective attention were recorded in 21 children at high-risk for schizophrenia and in 21 matched controls. The subjects performed a selective listening task. For behavioral evaluation, target counts on the selective listening task and on cognitive performance w...

journal_title：Biological psychiatry

authors： Schreiber H,Stolz-Born G,Kornhuber HH,Born J

更新日期：1992-10-15 00:00:00

abstract：:As many patients still require maintenance neuroleptic medication, it is important to determine what factors affect the course of tardive dyskinesia (TD) during ongoing neuroleptic treatment. In this study the data are from a series of annual examinations using the Abnormal Involuntary Movement Scale (AIMS) in a cohor...

journal_title：Biological psychiatry

authors： Bergen J,Kitchin R,Berry G

更新日期：1992-10-01 00:00:00

abstract：:Cerebrospinal fluid concentrations of corticotropin-releasing hormone (CRH), thyrotropin-releasing hormone (TRH) and somatostatin (SRIF) were measured in 77 female inpatients with moderate to extreme dementia and in 17 elderly female controls. Both multi-infarct (MID) and Alzheimer-type (SDAT) demented patients had eq...

journal_title：Biological psychiatry

authors： Banki CM,Karmacsi L,Bissette G,Nemeroff CB

更新日期：1992-09-01 00:00:00

abstract：:There are very few reports about asterixis as a side effect of treatment with psychopharmacologic agents. In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its...

journal_title：Biological psychiatry

authors： Rittmannsberger H,Leblhuber F

更新日期：1992-08-15 00:00:00

abstract：:Velocity of blood flow in the middle cerebral artery was measured with transcranial Doppler flowmeter before, during, and 1 hr after smoking a marijuana cigarette and a placebo cigarette during two separate visits to the laboratory. Ten healthy, right-handed male volunteers with a history of marijuana smoking took par...

journal_title：Biological psychiatry

authors： Mathew RJ,Wilson WH,Humphreys DF,Lowe JV,Wiethe KE

更新日期：1992-07-15 00:00:00

abstract：:The validity of previously hypothesized predictors of elapse following neuroleptic discontinuation was examined. One hundred sixty-two outpatients, with either Research Diagnostic Criteria schizophrenia or schizoaffective disorder, were discontinued from neuroleptic medication for a 28-day period or until judged to be...

journal_title：Biological psychiatry

authors： Buchanan RW,Kirkpatrick B,Summerfelt A,Hanlon TE,Levine J,Carpenter WT Jr

更新日期：1992-07-01 00:00:00

abstract：:Using auditory evoked responses, this work compares the reactivities to unimodal and crossmodal stimuli and the main neurocognitive functions most often disturbed in autism. With the aim of testing the hypothesis that the deficit in the ability to form crossmodal associations in autism is linked to a cognitive abnorma...

journal_title：Biological psychiatry

authors： Martineau J,Roux S,Garreau B,Adrien JL,Lelord G

更新日期：1992-06-15 00:00:00

abstract：:Conditioned responses to drug-related cues appear to be related to the maintenance of stimulant addiction. These conditioned responses are not blocked by treatments that block the direct effects of stimulants and may contribute to the high rate of relapse of addicts. Rats administered (+)-amphetamine in a specific env...

journal_title：Biological psychiatry

authors： DiLullo SL,Martin-Iverson MT

更新日期：1992-06-01 00:00:00

abstract：:Prolactin (PRL) and cortisol responses to oral administration of d-1 fenfluramine hydrochloride (60 mg) and placebo were examined in patients with endogenous major depressive disorder on three separate occasions: prior to treatment with clomipramine (CMI), after 4 weeks of CMI administration (175-250) mg/day), and 3 w...

journal_title：Biological psychiatry

authors： Shapira B,Yagmur MJ,Gropp C,Newman M,Lerer B

更新日期：1992-05-15 00:00:00

abstract：:Because recent research reports indicated clinical and biological differences in major depression with and without comorbid Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R) panic disorder, and as altered immune measures were reported in selected subgroups of depressive patients, we investigated 51 pai...

journal_title：Biological psychiatry

authors： Andreoli A,Keller SE,Rabaeus M,Zaugg L,Garrone G,Taban C

更新日期：1992-05-01 00:00:00

abstract：:Postmortem cerebellar and frontal cortical membrane homogenates from human alcoholics, control subjects without neurological or psychiatric illnesses, and rats that chronically drank alcohol were studied to determine the binding characteristics of an imidazobenzodiazepine, [3H]Ro 15-4513. This ligand binds to classica...

journal_title：Biological psychiatry

authors： Korpi ER,Uusi-Oukari M,Wegelius K,Casanova M,Zito M,Kleinman JE

更新日期：1992-04-15 00:00:00

abstract：:Several studies have indicated that patients with panic attacks have a higher rate of suicide attempts as well as deaths from suicide. Additionally, several investigators have presented case reports of individuals manifesting suicidal and violent behaviors directly and temporally associated with panic attacks. We repo...

journal_title：Biological psychiatry

authors： Korn ML,Kotler M,Molcho A,Botsis AJ,Grosz D,Chen C,Plutchik R,Brown SL,van Praag HM

更新日期：1992-03-15 00:00:00

abstract：:To examine directly in the brain the status of the alpha 2-adrenoceptor in major depression, the specific binding of the agonists [3H]clonidine and [3H]UK 14304 was quantitated in various brain regions of suicide victims with a retrospective diagnosis of depression or other psychiatric disorders. In depressed suicides...

journal_title：Biological psychiatry

authors： Meana JJ,Barturen F,García-Sevilla JA

更新日期：1992-03-01 00:00:00

abstract：:It has been proposed that the nailfold subpapillary plexus visibility score (PVS) may be a marker of susceptibility to schizophrenia. To further investigate this hypothesis, we evaluated plexus visibility in a sample of 61 chronic schizophrenics, a large sample of first-episode psychotic patients and their first-degre...

journal_title：Biological psychiatry

authors： Clementz BA,Iacono WG,Ficken J,Beiser M

更新日期：1992-02-15 00:00:00

abstract：:We have investigated the relationship between the concentration of homovanillic acid in human plasma (pHVA) and plasma anti-D1 and anti-D2 dopamine receptor activity in chronic schizophrenic patients whose neuroleptic dosage was changed. The change in pHVA level correlated with that in anti-D1, not anti-D2 activity, t...

journal_title：Biological psychiatry

authors： Suzuki E,Kanba S,Nibuya M,Koshikawa H,Nakaki T,Yagi G

更新日期：1992-02-15 00:00:00